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138,139 During endoscopy, biopsy samples were collected and analyzed by immunohistochemistry to quantify the expression of Ki67 (a marker of cell proliferation), as well as claudin-1 and claudin-4
Improvements are nevertheless reported with low initial doses and gradual titration according to patient tolerance (characterized as a marathon rather than a sprint)
Simple measures that help many people immediately include staying hydrated, trying small sips of water during episodes, practicing gentle swallowing techniques, avoiding throat clearing, and using a humidifier to reduce throat dryness
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